In Pico Roulette, Nene is one of the playable characters. Although Pico says he will protect her, Nene rebukes this, stating that she "can't wait to get her brains eaten" before running off. In Resident Pico, Nene appears at the start of the game to warn Pico about the incoming zombies. She is one of the playable characters, facing off against Übersam in a game of Rock Paper Scissors Roulette. Überkids, Nene is one of the few students left alive after the school shooting, along with Pico and Darnell. In Pico's School, Nene is in the school hallway, where she begs Pico to end her life due to her not wanting to live through the blood and violence any longer. If the razor blade is chosen, Nene has a brief conversation with her mother as she bleeds out. Ultimately, the choice is left to the player. Once she realizes her current situation, Nene decides to "die with honor" and kill herself by either drinking milk (as she is lactose intolerant), hanging herself on the ceiling fan, praying to the Lord and getting struck by a lightning bolt, jumping out of the window, shooting herself with a gun, or cutting her wrist open with a razor blade. In Nene Interactive Suicide, Nene wakes up with herpes after kissing " Jordan Katalano" the night before. She believes in dying "with honor," notably when discovering she had contracted herpes. She is also a Christian, as there is a bible on her nightstand, and she makes a prayer to God to end her life. Like Pico, she is very "popular" at school, claiming in Nene Interactive Suicide that she will be in the yearbook with Jordan Katalano as "Best Couple". Nene is a suicidal girl with an addiction to sharp melee weapons and promiscuous tendencies. They are also present in her images for the old Newgrounds art vote section, albeit significantly scaled down. In Pico Roulette, she is also shown with large buck teeth, much like a stereotypical depiction of an Asian. In Nene Interactive Suicide and Pico's School, she has herpes all over her mouth. Her hair is black and includes a pink headband. Nene wears a pink dress, lighter pink pants and shirt, and has slanted white eyes.